Birth-and-Death Process and Concerted Evolution

To explain evolution in MHC and immunoglobulin, scientists often used concerted evolution process, but recent research shows that multigene families of vertebrate immune systems evolve by birth-and-death process (36).

Concerted evolution often used to explain when the paralogous genes that are more closely related to each other in a species than the same gene family in another species. There are three requirements for concerted evolution process to be the case for an evolution process in a gene: 1. Amplification of genes by recombination. 2. Redistribution of genes by transposition. 3. Homogenization of alleles by gene conversion (4).

The birth-death process is a case of continuous-time Markov process that is a mathematical model. In this model, birth increases the state variable by one and death decreases the state variable by one. In evolution, birth is duplication of a gene and death is inactivation and elimination of a gene by deleterious mutation (36).

Fig 1

Figure 1 Three different models of evolution.